| CASE REPORT |
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| Year : 2019 | Volume
: 24
| Issue : 1 | Page : 57-59 |
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Disulfiram-induced psychosis at a therapeutic dose and in clear sensorium: Two case demonstrations
Abhishek Ghosh1, Debasish Basu1, C Pradeep2, BN Subodh1
1 Department of Psychiatry, Drug De-Addiction and Treatment Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 VMKV Medical College and Hospital, Salem, Tamil Nadu, India
Correspondence Address:
Abhishek Ghosh
Department of Psychiatry, Drug De-Addiction and Treatment Center, Postgraduate Institute of Medical Education and Research, Chandigarh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jmhhb.jmhhb_1_19
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The literature on disulfiram induced psychosis showed, it was either associated with delirium or preceded by a prescription of a higher dose. We report two cases of psychosis in clear sensorium developing in individuals with alcohol dependence without any familial loading following a short duration of a therapeutic dose of disulfiram. Before the onset of psychosis, the patients were abstinent from alcohol for about a month, which made substance-induced psychosis unlikely. Psychosis resolved following discontinuation of disulfiram. Hence, the diagnosis of disulfiram-induced psychosis was considered. A plausible mechanism of such association has been discussed. Disulfiram-induced psychosis though unusual could be disruptive and severe. Close surveillance following disulfiram is important for early identification and management of such condition.
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