Journal of Mental Health and Human Behaviour

CASE REPORT
Year
: 2019  |  Volume : 24  |  Issue : 1  |  Page : 57--59

Disulfiram-induced psychosis at a therapeutic dose and in clear sensorium: Two case demonstrations


Abhishek Ghosh1, Debasish Basu1, C Pradeep2, BN Subodh1 
1 Department of Psychiatry, Drug De-Addiction and Treatment Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 VMKV Medical College and Hospital, Salem, Tamil Nadu, India

Correspondence Address:
Abhishek Ghosh
Department of Psychiatry, Drug De-Addiction and Treatment Center, Postgraduate Institute of Medical Education and Research, Chandigarh
India

The literature on disulfiram induced psychosis showed, it was either associated with delirium or preceded by a prescription of a higher dose. We report two cases of psychosis in clear sensorium developing in individuals with alcohol dependence without any familial loading following a short duration of a therapeutic dose of disulfiram. Before the onset of psychosis, the patients were abstinent from alcohol for about a month, which made substance-induced psychosis unlikely. Psychosis resolved following discontinuation of disulfiram. Hence, the diagnosis of disulfiram-induced psychosis was considered. A plausible mechanism of such association has been discussed. Disulfiram-induced psychosis though unusual could be disruptive and severe. Close surveillance following disulfiram is important for early identification and management of such condition.


How to cite this article:
Ghosh A, Basu D, Pradeep C, Subodh B N. Disulfiram-induced psychosis at a therapeutic dose and in clear sensorium: Two case demonstrations.J Mental Health Hum Behav 2019;24:57-59


How to cite this URL:
Ghosh A, Basu D, Pradeep C, Subodh B N. Disulfiram-induced psychosis at a therapeutic dose and in clear sensorium: Two case demonstrations. J Mental Health Hum Behav [serial online] 2019 [cited 2022 Aug 16 ];24:57-59
Available from: https://www.jmhhb.org/article.asp?issn=0971-8990;year=2019;volume=24;issue=1;spage=57;epage=59;aulast=Ghosh;type=0